The recent past has seen major advances in the understanding of the genetic and genomic architecture of neurodevelopmental disorders. We now have a deeper understanding of how genetic risk for many complex traits including neurodevelopmental disorders is driven by natural selection and distributed across the allelic spectrum.
While reliable results have emerged for conditions ranging from schizophrenia to bipolar disorder to autism, providing important insights into aspects of the neurobiology of these syndromes, a comprehensive understanding of their underlying biology is still out of reach.
In addition to the emerging genetic and molecular advances, there is the increasing realization that neurodevelopmental disorders target specific brain circuits. The interaction between genetic background, brain structure, and brain function is now the scientific background upon which specific neurodevelopmental conditions can be studied and understood.
Looking forward, systems integration of multiple levels of biological hierarchy—from genes, molecules, cells, and circuits to behavior and clinical outcomes—will illuminate causal models of disease and further establish this field as a component of precision medicine. We have been fortunate to assemble an extraordinary group of speakers to address this question.
10:10 a.m. Tom Maniatis, PhD: Welcome
10:13 a.m. Thomas Lehner, PhD, MPH, Moderator
10:15 a.m. Mark Daly, PhD, Harvard Medical School, University of Helsinki
10:55 a.m. Elise Robinson, ScD, Harvard T.H. Chan School of Public Health
11:35 a.m. Matthew State, MD, PhD, University of California, San Francisco
12:15 p.m. David Goldstein, PhD, Columbia University
12:55 p.m. Lunch break
2:00 p.m. Sergiu Pasca, MD, Stanford University
2:40 p.m. Nenad Sestan, MD, PhD, Yale School of Medicine
3:20 p.m. Kristen Brennand, PhD, Yale School of Medicine
4:00 p.m. Huda Zoghbi, MD, Baylor College of Medicine