Past Event

Precision Medicine Conference:Genetics of Neurodevelopmental Disease

April 7, 2021
10:10 AM - 4:50 PM
Online Event Zoom Webinar

Fifth Annual Columbia Precision Medicine Initiative (CPMI) conference, Advances in Precision Medicine: Genetics of Neurodevelopmental Disease.

Due to the COVID-19 pandemic, this year’s conference is taking place online.


The recent past has seen major advances in the understanding of the genetic and genomic architecture of neurodevelopmental disorders. We now have a deeper understanding of how genetic risk for many complex traits including neurodevelopmental disorders is driven by natural selection and distributed across the allelic spectrum.

While reliable results have emerged for conditions ranging from schizophrenia to bipolar disorder to autism, providing important insights into aspects of the neurobiology of these syndromes, a comprehensive understanding of their underlying biology is still out of reach.

In addition to the emerging genetic and molecular advances, there is the increasing realization that neurodevelopmental disorders target specific brain circuits. The interaction between genetic background, brain structure, and brain function is now the scientific background upon which specific neurodevelopmental conditions can be studied and understood.

Looking forward, systems integration of multiple levels of biological hierarchy—from genes, molecules, cells, and circuits to behavior and clinical outcomes—will illuminate causal models of disease and further establish this field as a component of precision medicine. We have been fortunate to assemble an extraordinary group of speakers to address this question.

  • 10:10 a.m. Tom Maniatis, PhD: Welcome
  • 10:13 a.m. Thomas Lehner, PhD, MPH, Moderator
  • 10:15 a.m. Mark Daly, PhD, Harvard Medical School, University of Helsinki
  • 10:55 a.m. Elise Robinson, ScD, Harvard T.H. Chan School of Public Health
  • 11:35 a.m. Matthew State, MD, PhD, University of California, San Francisco
  • 12:15 p.m. David Goldstein, PhD, Columbia University
  • 12:55 p.m. Lunch break
  • 2:00 p.m. Sergiu Pasca, MD, Stanford University
  • 2:40 p.m. Nenad Sestan, MD, PhD, Yale School of Medicine
  • 3:20 p.m. Kristen Brennand, PhD, Yale School of Medicine
  • 4:00 p.m. Huda Zoghbi, MD, Baylor College of Medicine
  • 4:40 p.m. Tom Maniatis, PhD: Final Remarks

Contact Information

Betsy MacLeod
(917) 658-8207